Martin Johnson has named his side to meet Australia at Twickenham on saturday.
Number eight Jordan Crane and inside centre Shane Geraghty, both 23, get first Test starts, with the uncapped pair of Courtney Lawes and Ayoola Erinle both on the bench.
Monye, normally a winger but who has been playing at full-back for Harlequins this season, will wear the 15 shirt with Matt Banahan and Mark Cueto on the wings.
Geraghty and Dan Hipkiss form the centre partnership while Danny Care edges out Paul Hodgson for the scrum-half shirt. Crane, who has previously won two caps off the bench, makes his first Test start in an all-Leicester back row alongside Croft and Moody.
In the front row Thompson packs down between Wilson, who wins his third cap, and Wasps loose-head Tim Payne, while Borthwick and Louis Deacon continue the second row partnership which started both summer Tests against Argentina.
U Monye (Harlequins); M Cueto (Sale Sharks), D Hipkiss (Leicester), S Geraghty (Northampton), M Banahan (Bath); J Wilkinson (Toulon), D Care (Harlequins); T Payne (Wasps), S Thompson (Brive), D Wilson (Bath), L Deacon (Leicester), S Borthwick (Saracens, capt), T Croft (Leicester), L Moody (Leicester), J Crane (Leicester).
Replacements: D Hartley (Northampton), D Bell (Bath), C Lawes (Northampton), J Haskell (Stade Francais), P Hodgson (London Irish), A Goode (Brive), A Erinle (Biarritz).
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